EFSA and the PPR Panel have started in 2007 the development of methodologies to carry out cumulative risk assessment for Maximum Residue Levels setting which implies the establishment of cumulative assessment groups (CAGs) of pesticidal active substances on the basis of their toxicological properties. The aims of the present project is to finalise the collection of data for the nervous system (Task 1), the thyroid (Task 2), the reproductive and developmental system (Task 3) and the liver (Task 4) by collecting and analysing toxicological data for pesticides approved within the EU as well as for pesticidal active substances not approved for use within the EU, but detected as residues in food or feed. In addition, the collection of data has been performed for two other organs namely the adrenal (Task 5) and the eye (Task 6). Information on toxicological effects has been primarily retrieved from regulatory toxicological studies provided in support of approval and their evaluations under the peer review process of Directive 91/414/EC and Regulation (EC) 1107/2009. For each organ/system separately, a data collection table has been drawn according to a methodology agreed by EFSA and the consortium including a predefined list of specific effects and their related indicators. Based on the collection table of each organ/system, preliminary CAGs have been proposed by the consortium. Furthermore, the collection tables would allow EFSA to access the relevant toxicological information necessary to define consolidated CAGs according to the criteria adopted in the PPR opinion on cumulative assessment groups (CAGs) EFSA Journal 2013;11(7):3293.
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